Hoãn
| Burnley | 0 - 2 | Leicester |
| Đà Nẵng | 0 - 0 | CLB TP.HCM |
| Gia Lai | 0 - 0 | Hà Tĩnh |
| Hải Phòng | 2 - 1 | Nam Định |
| Peterborough United | 0 - 2 | Man City |
| Crystal Palace | 2 - 1 | Stoke City |
| Middlesbrough | 1 - 0 | Tottenham |
| Cardiff City | 1 - 0 | Derby County |
| Benevento | 1 - 1 | Cremonese |
| Brescia | 2 - 1 | Perugia |
| Ternana | 1 - 0 | Pordenone Calcio |
| Alessandria | 1 - 1 | Como |
| AC Milan | 0 - 0 | Inter |
| Nice | 2 - 0 | Versailles |
| Kawasaki Frontale | 2 - 1 | Urawa Red Diamonds |
| Jeonbuk FC | 0 - 1 | Pohang Steelers |
| Yokohama F.Marinos | 2 - 0 | Vissel Kobe |
| Daegu FC | 1 - 0 | Sangju Sangmu |
| Marumo Gallants | 3 - 0 | Baroka FC |
| Orlando Pirates | 0 - 0 | Cape Town City FC |
| Chippa United | 23:00 | Tshakhuma FC |
| Icasa | 0 - 0 | Tombense FC |
| FC Emmen | 1 - 2 | Helmond Sport |
| Marica FC | 0 - 1 | Guarani |
| Queen's Park | 2 - 1 | Peterhead |
| Pouso Alegre | 2 - 0 | Parana Clube |
| Moto Club MA | 3 - 2 | Chapecoense AF |
| Velez Sarsfield | 5 - 0 | Club Cipolletti |
| Mirassol | 3 - 2 | Gremio |
| Sousa | 1 - 1 | Goias |
| Colon | 2 - 1 | Club Sportivo Penarol |
| Boluspor | 0 - 1 | Tuzlaspor |
| Trabzonspor | 2 - 0 | Antalyaspor |
| Pharco FC | 1 - 4 | Al Ahly |
| Union Berlin | 2 - 1 | St. Pauli |
| Sivasspor | 1 - 0 | Fatih Karagumruk |
| Deportes Santa Cruz | 1 - 2 | Magallanes |
| Santiago Wanderers | 2 - 2 | Santiago Morning |
| Neftchi Fargona | 1 - 0 | Kokand 1912 |
| Olympic | 0 - 0 | Surkhon-2011 |
| C.S. Cartagines | 1 - 1 | Deportiva San Carlos |
| Melbourne City FC | 2 - 2 | Perth Glory |
| Guastatoya | 4 - 1 | Nueva Concepcion |
| Deportivo Pasto | 1 - 1 | Alianza Petrolera |
| Independiente Medellin | 4 - 0 | Rionegro Aguilas |
| Montana | 0 - 5 | Ludogorets |
| Al-Duhail SC | 6 - 1 | Umm Salal |
| Septemvri Sofia | 0 - 2 | Levski Sofia |
| Al-Arabi | 2 - 1 | Al-Gharafa |
| Puebla | 1 - 1 | FC Juarez |
| Toluca | 1 - 2 | Tijuana |
| CF America | 1 - 1 | Queretaro FC |
| Leon | 0 - 0 | Monterrey |
| Mazatlan FC | 0 - 0 | Necaxa |
| Noravank | 1 - 2 | Pyunik |
| Ararat Armenia | 0 - 0 | BKMA |
| Alashkert FC | 21:00 | Van |
| Ararat | 21:00 | Urartu FC |
| Sevan | 21:00 Dừng | Noravank |
| Alebrijes Oaxaca | 1 - 0 | Celaya |
| Correcaminos de la UAT | 0 - 1 | Cancun FC |
| Metalist Kharkiv | 00:30 Hoãn | Zorya |
| Oleksandriya | 22:00 Hoãn | Dynamo Kyiv |
| Parnu JK Vaprus | 1 - 3 | Paide Linnameeskond |
| Nomme JK Kalju | 1 - 0 | FC Kuressaare |
| Servette | 1 - 0 | Young Boys |
| Schaffhausen | 0 - 1 | FC Stade Lausanne-Ouchy |
| Thun | 1 - 2 | Xamax |
| Wil | 3 - 1 | Kriens |
| FC Gareji 1960 | 1 - 1 | FC Zugdidi |
| WIT Georgia Tbilisi | 0 - 0 | Samtredia |
| Radomlje | 0 - 0 | Tabor |
| Mura | 2 - 2 | NK Celje |
| FC Kosice | 1 - 2 | Spartak Trnava |
| FC STK 1914 Samorin | 1 - 1 | Skalica |
| MFK Vranov Nad Toplou | 1 - 2 | FK Pohronie |
| Trencin | 3 - 1 | Humenne |
| Proleter | 0 - 3 | FK Spartak Subotica |
| FK Metalac | 1 - 1 | Radnicki Nis |
| TSC Backa Topola | 0 - 0 | FK Radnik Surdulica |
| Buducnost Dobanovci | 1 - 0 | Radnicki Sremska Mitrovica |
| FK Graficar | 1 - 1 | Indjija |
| Timok | 0 - 1 | Loznica |
| Backa Palanka | 2 - 2 | Javor |
| Macva Sabac | 23:00 | Zarkovo |
| U Craiova 1948 | 3 - 2 | Rapid Bucuresti |
| FC Academica Clinceni | 2 - 0 | Gaz Metan Medias |
| CS Mioveni | 0 - 3 | CS Universitatea Craiova |
| Olimpia Grudziadz | 1 - 1 | Wisla Krakow |
| Arka Gdynia | 0 - 2 | Rakow Czestochowa |
| Panathinaikos | 23:00 Hoãn  |
